You can’t deny it. Exogenous ketones are one of the hottest products on the market right now, especially for those interested in ketosis and the ketogenic diet. But what exactly are exogenous ketones, and what do they offer? We’ll dive into that in this in-depth guide about how to benefit from supplementing with exogenous ketones.
Exogenous ketones come in different forms and even more importantly can be used for several different applications. Fat burning, reducing ketosis symptoms, enhancing physical performance and mental performance are some of the ways that ketones can be used.
WHAT IS KETOSIS?
If you are new to ketosis and don’t know much about it, it is a metabolic state, where your body preferentially uses ketones (instead of glucose) for energy. This can lead to a host of different health benefits. If you’d like to learn more about ketosis, what ketones are, and how to benefit from these, feel free to read through our guides: What is Ketosis? What is the Ketogenic Diet? What Are Ketones?
TYPES OF EXOGENOUS KETONES
If you’ve read our guide, What Are Ketones, you’ll know that there are three different types of ketones your body can make in the absence of carbohydrates, typically from stored fat. However, there are ways to get ketones easily from exogenous (outside of your body) sources.
There are three different types of “ketones” that your body runs on: Acetoacetate, beta-hydroxybutyrate, and acetone. Beta-hydroxybutyrate is the active form that can flow freely in the blood and be used by your tissues, so that is the one that most exogenous ketone supplements are based off.
Ketone esters are the raw ketone (in this case, beta-hydroxybutryate) that is not bound to any other compound. These exogenous ketones can be utilized a little quicker and potentially have a better effect at raising blood ketone levels as your body doesn’t have to cleave the BHB from any other compound, however, there are some trade offs.
Most users of traditional ketone esters claim that the taste is nearly unbearable. Also, gastric distress is a very common side effect.
Another form of exogenous ketone supplements come in the form of ketone “salts.” This is where the ketone body (again, typically beta-hydroxybutyrate) is bound to a salt — sodium, calcium, magnesium or potassium generally.
While ketone salts may not raise ketone levels to an absurd amount like true ketone esters, the taste is much more manageable and the potential diarrhea side effects are lessened to a great degree. For the majority of the population, this is the type of ketone supplement they should be looking for.
MCT (medium chain triglyceride) oil, and other medium to smaller chain fats can be used to help boost ketones as well, however this is through an indirect pathway.
Whereas beta-hydroxybutryate from ketone salts or esters can be immediately used for energy, MCTs have to be shuttled to cells to be broken down, which then ketone bodies are made as a byproduct, only then can be used for energy.
The downsides to MCT oil for ketones is that they do little in raising the actual blood levels of ketones. MCT oil is quite calorically dense as well, meaning that it’s not a great solution for those looking to keep calories low and burn fat.
WHY EXOGENOUS KETONES
There are times when eating a fully ketogenic diet is not realistic or desired. It can be very restrictive and difficult for a lot of people to follow. Some people may feel lower energy with a full ketogenic diet, so they can use exogenous ketones as a targeted way to get the benefits of ketosis in between meals.
If you are an athlete and need to eat carbohydrates for performance, you’ll never be able to get the full benefits from ketosis as you’ll never be able to be fully in it. You will need carbs around a workout, but also, you may want ketones to power a longer workout. This is where exogenous ketone supplementation can be beneficial.
If you’re a normal person but you’re generally following ketosis, there are often times when you eat certain foods or do certain things that kick you out of ketosis. If you eat too many carbs, you can take exogenous ketones to get you back into ketosis instantly instead of waiting 2-3 days.
WHEN TO USE EXOGENOUS KETONES
For Fat Burning
This is a very popular benefit that many people are looking for when they are looking into ketosis. Taking exogenous ketones doesn’t make you magically burn fat, however, it does get you into ketosis quickly.
Taking exogenous ketones will let your body know that it is time to use ketones. When you’re done using the exogenous ketones as fuel, your body will start asking for other places to get ketones from. This would be fat.
In general, more ketosis equals more fat burning.
How To: Use a scoop to help transition into ketosis or to boost your body’s ability to burn ketones (and fat) as energy.
When you want to get back into ketosis quickly
Not everyone can follow a very strict, high fat, low carb diet. For those who have done ketosis before, they will know that when you get kicked out of ketosis, it can take awhile to get back in. Not anymore. You can use exogenous ketones to ramp your body back into ketosis effortlessly.
Using exogenous ketone supplements shortly after a meal with carbohydrates will tell your body that you want to be using ketones for energy instead of those carbs. Instead of eating very low carb for days, you can just take a scoop of exogenous ketones and get back into ketosis.
This makes it so you don’t have to go through the awful “keto flu” phase, which is where all the of the nasty side effects are.
How To: Take 1/2 of a serving of exogenous ketones when transitioning to ketosis.
To avoid the “keto flu”
When your body transitions from using energy from carbohydrates to ketones, there can be a lot of nasty and unwanted side effects. These include low energy, bloating, irritability, headaches and fatigue. This is because your body is “in between” burning carbs and burning ketones and hasn’t become efficient at burning ketones and producing them from your fat stores yet.
The good news is that you can use exogenous ketones to bridge the gap. While your body is getting used to using ketones, you can supply it with energy to eliminate all of these nasty side effects where it otherwise would be struggling to find efficient energy.
How To: Split into smaller doses of 1/3 – 1/2 scoop and spread throughout the day for 3-5 days while transitioning to ketosis.
For endurance exercise benefits
When your body has demands of physical performance, there are a few different energy systems it can use. These require different types of fuel.
If you have very explosive demands, such as sprints or quick movements, your energy should be coming from carbohydrates. This will come from stored glycogen. However, your body only has a certain amount of stored glycogen to use for explosive movements.
When you run out of glycogen, your body can either make more, or start making energy from fat. Both of these processes are dependent on using oxygen for energy. However, when you take exogenous ketones, your body can use that energy immediately with a much lower oxygen utilization.
This transfers especially well to endurance exercise, where a big limitation is the amount of oxygen that is available for energy throughout the exercise. With exogenous ketones, you can
How To: Take a scoop before a workout that will last 45 minutes or longer. Take another 1/2 scoop for each hour after 2 hours of continuous work. This can be helpful for marathons, triathlons, and ultra runs.
For mental productivity
Your brain has a very tight barrier so not everything in the blood can get through. This is called the blood brain barrier. Because your brain uses 25% of the energy that your entire body uses throughout the day, you need to make sure it is fueled appropriately. Glucose can’t directly cross the blood brain barrier. When you eat carbs, you get swings in energy that is available to cross the blood brain barrier which leads to mental fog.
Ever feel mentally foggy after you eat a super dense carb meal? That is the dip in energy and a ton of metabolic processes trying to shuttle glucose around your body. No one wants to feel mentally foggy, so good thing there are exogenous ketones.
Ketones, however, are small enough to cross the blood brain barrier readily. This means you can have a constant supply of energy to the brain, with no other processing needed. If you’re not always in a state of ketosis, you won’t always have a supply of ketones to the brain.
This is when you can take exogenous ketones. Think of one of the benefits of exogenous ketones as on demand brain fuel. If you need some mental energy, you can take exogenous ketones on an empty stomach and they will readily cross the blood brain barrier and be used as such.
Many high performers, such as Tim Ferriss, use exogenous ketones for mental performance and many other benefits.
How To: Take a scoop of exogenous ketones on an empty stomach for 4-6 hours of mental energy boosts.
As you can see, there are plenty of ways to use exogenous ketones for benefits. We do offer an exogenous ketone product, called Perfect Keto Base. Perfect Keto Base comes in two flavors: chocolate sea salt and peaches & cream.
How do you use exogenous ketones? Any results that you are getting that could help someone else? Let us know in the comments below!
Dr. Anthony Gustin is a board-certified sports chiropractor, functional medicine practitioner, entrepreneur, podcast host, and founder of Perfect Keto.
Over the last few years, he has treated thousands of patients with movement rehab, internal diagnostics, and natural interventions, including NFL, MLB and NBA champions. After growing his sports rehab and functional medicine clinics to six locations in San Francisco, he shifted his mission to help as many people as possible achieve optimal health and well-being.